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MYP_041170
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Basic Information
Brevinin-2LTb (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
33 amino acids
C148H266N42O42S2
Standard
Sequence
SILDKIKNVALGVARGAGTGILKALLCKLDKSC
Physicochemical Analysis
3370.08 Da
9.59
3.44
3.19
0.1042
0.56
0.57
0.14
2.95
136.06
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1364.90
-12.80
50.0
48.0
120.0
234.0
0.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0302032 VERIFIED: YES
Provenance & Taxonomy
Hylarana latouchii [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
PMID22426384 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22426384/
RECORD: Rec_0313343 VERIFIED: YES
Provenance & Taxonomy
Hylarana latouchii [Animal]
Brevinin
156873
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial
Escherichia coli ATCC 25922
30 μM
MIC
PaperMolecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii.
RECORD: Rec_0341873 VERIFIED: YES
Provenance & Taxonomy
Hylarana latouchii [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
30 μM
MIC
PMID22426384 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22426384/
RECORD: Rec_0353849 VERIFIED: YES
Provenance & Taxonomy
Hylarana latouchii [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Rhodococcus rhodochrous X15
1.9 μM
MIC
PMID22426384 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22426384/
RECORD: Rec_0354537 VERIFIED: YES
Provenance & Taxonomy
Hylarana latouchii [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
human erythrocytes
480 μM
LD50
PMID22426384 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22426384/
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