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MYP_041170
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Basic Information
Brevinin-2LTb (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
33 amino acids
C148H266N42O42S2
Standard
Sequence
SILDKIKNVALGVARGAGTGILKALLCKLDKSC
Physicochemical Analysis
3370.08 Da
9.59
3.44
3.19
0.1042
0.56
0.57
0.14
2.95
136.06
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1364.90
-12.80
50.0
48.0
120.0
234.0
0.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000934 VERIFIED: YES
Provenance & Taxonomy
Hylarana latouchii [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus licheniformis X39
3.8 μM
MIC
PMID22426384 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22426384/
RECORD: Rec_0023571 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
480 μM
LD50
Paperhttps://pubmed.ncbi.nlm.nih.gov/22426384/ PMID22426384 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22426384/
RECORD: Rec_0048713 VERIFIED: YES
Provenance & Taxonomy
Hylarana latouchii [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
27-33
Bio-Activity Profile
Antimicrobial Antibacterial
PaperH. Wang et al. / Peptides 30 (2009) 273-282. The novel antimicrobial peptides from skin of Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae) Evidence URLhttps://www.uniprot.org/uniprotkb/B9W1P9/entry
RECORD: Rec_0090458 VERIFIED: YES
Provenance & Taxonomy
Hylarana latouchii [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC2592
3.8 μM
MIC
PMID22426384 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22426384/
RECORD: Rec_0120517 VERIFIED: YES
Provenance & Taxonomy
Hylarana latouchii [Animal]
Brevinin
156873
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus ATCC 2592
3.8 μM
MIC
PaperMolecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii.
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