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MYP_041133
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Basic Information
R9
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiviral
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
9 amino acids
C54H110N36O10
Standard
Sequence
RRRRRRRRR
Physicochemical Analysis
1423.69 Da
12.00
8.76
8.56
0.9733
-4.50
0.37
-2.53
518.04
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
853.22
-11.35
37.0
19.0
53.0
100.0
0.0
8.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0221456 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Palustrin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 25923[60-70% Inhibition = 20 microM
PMID22023266;24243601;26922474;20920465 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22023266/
RECORD: Rec_0237430 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Palustrin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 25923[40-50% Inhibition = 10 microM
PMID22023266;24243601;26922474;20920465 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22023266/
RECORD: Rec_0240029 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Protease inhibitor
Human cytomegalovirus (Furin); CHO
0.042 μM
Ki
PaperPolyarginines are potent furin inhibitors. | Cameron A, Appel J, Houghten RA, Lindberg I. | J Biol Chem. 2000 | PMID:10958789 PMID10958789 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10958789/
RECORD: Rec_0248355 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Polyarginine
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Φ, L-2-naphthylalanine,miniPEG, 8-amino-3,6-dioxaoctanoic acid
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID24896852 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24896852/
RECORD: Rec_0261312 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Oligoarginine
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Fluorescein/FITC labeling
None
N-term detail: Fluorescein-tagged
Bio-Activity Profile
Cell-penetrating peptide
HeLa
Fluorescence-based uptake assay
PMID12411431 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12411431/
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