Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length432 amino acids

Chemical FormulaC2163H3415N529O610S18

DescriptionStandard

        MLPFLILLLPCTNHAFGLNPAIKAVLANKGLKYGTHIGTDWMHEKILSMKVPDVTGGVYIGFGTVKYVLDGISVSSCDVPEPSVNFSEGSGLKIVINGLSIAVRGNWHTTFGIITDGGSFDLAVFNLDLTLLVDIGSDDKGHMSILSKYCSARINSATINFHGGASWIFQPFVDCFKSRIKALIEEKICPLVDQHVADLEQYLTELQVSFQIDPIVVLDVPLTNAPLISSSSLGLDLKGEFYSIKSPKEPPFEAKAFDLFNSASYAYFDTGHLHITVTDEMVSHQPLLCLPKLFPNMLMLLEVYAREIPMFSFLPGEVTLDFPGAVKALAILPNRTLTPLFKLNADSLFSGKVYISEGKLKGLMELKNFTLTLASSEIGTFQTAALEKGVNMLMKISVLSVLNAKLKEGIALPTIRSLNFVNSVLKVQQVCI
    

Molecular Weight47167.60 Da

Isoelectric Point (pI)5.94

Net Charge (pH 7.0)-5.66

Net Charge (pH 7.4) -6.59

Charge Density (pH 7.0) -0.0131

GRAVY Index0.34

Hydrophobic Moment 0.65

Boman Index0.22

Instability Index28.86

Aliphatic Index 110.32

Aromaticity 0.0903

Extinction Coeff. Reduced 31400.00

Extinction Coeff. Oxidized 31775.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0003550 VERIFIED: NO

Provenance & Taxonomy

OrganismEsox lucius [Animal]

FamilyBPI

Tax ID8010

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence