Peptide Database

Peptide NameSLAY-screened peptide P1292

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC99H165N39O30

DescriptionStandard

        LSNNRRLHHIAGPRENLVNGN
    

Molecular Weight2381.61 Da

Isoelectric Point (pI)11.70

Net Charge (pH 7.0)1.94

Net Charge (pH 7.4) 1.63

Charge Density (pH 7.0) 0.0922

GRAVY Index-1.06

Hydrophobic Moment 0.40

Boman Index-0.28

Instability Index42.93

Aliphatic Index 92.86

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1152.57

LogP -15.32

H-bond Donors 39.0

H-bond Acceptors 34.0

Rotatable Bonds 79.0

Heavy Atoms 168.0

Ring Count 3.0

Amide Bonds 25.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0335037 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/