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MYP_041088
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Basic Information
Diketopiperazine (prewa)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
2 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XA
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0006808 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
all-D amino-acid peptide [D]
None
None
x=Prenylated-D-Trp
Bio-Activity Profile
Antimicrobial Anticancer
A2780
85 μM
IC50
PMID22617493 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22617493/
RECORD: Rec_0016273 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
X=Prenylated-Trp
Bio-Activity Profile
Antimicrobial Anticancer
A2780
77.2 μM
IC50
PMID22617493 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22617493/
RECORD: Rec_0020520 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
residue-level stereochemical modification [Mixed]
Carbobenzoxy
CH2F
Bio-Activity Profile
Antiparasitic Antimicrobial Antiplasmodial Cysteine protease inhibitor
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0036713 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
X=Prenylated-Trp
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID22617493 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22617493/
RECORD: Rec_0068604 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
X=Prenylated-Trp
Bio-Activity Profile
Antimicrobial Anticancer
A2780-cisR
82.2 μM
IC50
PMID22617493 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22617493/
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