‹ ›
MYP_041078
← PREVIOUS NEXT → BACK
Basic Information
Cathelicidin-5 , Antibacterial peptide BMAP-28 , Myeloid antibacterial peptide 28
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
28 amino acids
C147H252N44O31
Standard
Sequence
GGLRSLGRKILRAWKKYGPIIVPIIRIG
Physicochemical Analysis
3131.85 Da
12.00
6.76
6.55
0.2413
0.23
0.95
0.07
48.16
139.29
0.0714
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1213.35
-6.15
45.0
38.0
105.0
222.0
5.0
27.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0412431 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Cathelicidin
9913
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
stereochemistry not specified [Other]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus (MRSA)
4 μM
MIC
PMID8910461;8706679 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8910461/
RECORD: Rec_0413653 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Cathelicidin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HSV Entry inhibition
Herpes simplex virus type 1(HSV-1) | Vero cells
5 μM
% inhibition
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperIn vitro and in vivo antimicrobial activity of two alpha-helical cathelicidin peptides and of their synthetic analogs. | Benincasa M, Skerlavaj B, Gennaro R, Pellegrini A, Zanetti M. | Peptides. 2003 Nov;24(11):1723-31. | DOI:10.1016/j.peptides.2003.07.025 | PMID:15019203 PMID15019203 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15019203/
RECORD: Rec_0416797 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Cathelicidin
9913
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli D21
0.5 μM
MIC
PMID8910461;29103679 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8910461/
RECORD: Rec_0426292 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Cathelicidin
9913
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
a 27mer was made with C-terminal amidation (implied by last G)
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Anticancer Antiparasitic
Pseudomonas aeruginosa ATCC 27853
1 μM
MIC
PaperBiological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities.
RECORD: Rec_0426889 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Cathelicidin
9913
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
a 27mer was made with C-terminal amidation (implied by last G)
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Anticancer Antiparasitic
S. marcescens ATCC 8100
2 μM
MIC
PaperBiological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities.
FIRST PREV 1 ... 8 9 10
Showing 5 records on this page · Page 10 of 10