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MYP_040999
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Basic Information
Temporin-B (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
13 amino acids
C67H121N15O16
Standard
Sequence
LLPIVGNLLKSLL
Physicochemical Analysis
1392.77 Da
8.75
0.76
0.55
0.0584
1.64
0.51
0.54
-2.08
232.31
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
493.07
-0.67
16.0
17.0
46.0
98.0
1.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0267546 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Temporin
8407
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HSV Entry inhibition
Herpes simplex virus 1 (HSV-1) | Vero cells
1.8 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperThe Amphibian Antimicrobial Peptide Temporin B Inhibits In Vitro Herpes Simplex Virus 1 Infection. | Marcocci ME, Amatore D, Villa S, Casciaro B, Aimola P, Franci G, Grieco P, Galdiero M, Palamara AT, Mangoni ML, Nencioni L. | Antimicrob Agents Chemother. 2018 Apr 26;62(5):e02367-17. | DOI:10.1128/AAC.02367-17 | PMID:29483113 PMID29483113 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29483113/
RECORD: Rec_0268156 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli D21
PMID9022710 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9022710/
RECORD: Rec_0297535 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Plant]
Temporin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC15692
360 μM
LC
PMID9022710;28443279 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9022710/
RECORD: Rec_0320971 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Plant]
Temporin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
48 μM
MIC
PMID9022710;28443279 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9022710/
RECORD: Rec_0332022 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Plant]
Temporin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Candida albicans
4.0 μM
LC
PMID9022710;28443279 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9022710/
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