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MYP_040999
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Basic Information
Temporin-B (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
13 amino acids
C67H121N15O16
Standard
Sequence
LLPIVGNLLKSLL
Physicochemical Analysis
1392.77 Da
8.75
0.76
0.55
0.0584
1.64
0.51
0.54
-2.08
232.31
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
493.07
-0.67
16.0
17.0
46.0
98.0
1.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0126600 VERIFIED: NO
Provenance & Taxonomy
Rana temporaria [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperPatent US 10723764 B2 Evidence URLhttps://patents.google.com/patent/US10723764B2/en PatentUS 10723764 B2
RECORD: Rec_0138982 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Plant]
Temporin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PMID9022710;28443279 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9022710/
RECORD: Rec_0139197 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Temporin
8407
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
C-terminal amidated. The D-form was found to be more active and stable than the L-form (D>L; Herin OH et al 2000 Antimicrob Agents Chemother 44:68-72)
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Antiparasitic Toxicity
Escherichia coli D21
21 μM
LC50
PaperTemporins, antimicrobial peptides from the European red frog Rana temporaria.
RECORD: Rec_0139621 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Toxic Hemolytic Anti-Gram-positive Antileishmanial Anti-Gram-negative
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0144122 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Plant]
Temporin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Yersinia pseudotuberculosis
7.0 μM
LC
PMID9022710;28443279 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9022710/
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