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MYP_040954
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Basic Information
[D9k]Hymenochirin-1B
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
29 amino acids
C141H258N38O35S
Standard
Sequence
IKLSPETKKNLKKVLKGAIKGAIAVAKMV
Physicochemical Analysis
3077.86 Da
10.48
6.75
6.54
0.2329
0.16
0.69
0.03
12.77
124.48
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1198.34
-8.04
41.0
43.0
113.0
215.0
1.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0327197 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
①Introduction of D-amino acid(s). (Look at 'Stereochemistry')
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
maltophilia
3.1 μM
MIC
PaperAn analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties PMID24172540 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24172540/
RECORD: Rec_0343098 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Stenotrophomonas maltophilia
3.1 μM
MIC
PMID24185042;24172540 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24185042/
RECORD: Rec_0343576 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Klebsiella pneumoniae ATCC 700603
12.5 μM
MIC
PMID24185042;24172540 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24185042/
RECORD: Rec_0345953 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer
mirabilis
100 μM
MIC
PaperAn analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties. Peptides. 2013 Dec;50:153-9. doi: 10.1016/j.peptides.2013.10.015. PMID: 24172540 PMID24172540;30789695 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24172540/
RECORD: Rec_0346989 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer
maltophilia
3.1 μM
MIC
PaperAn analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties. Peptides. 2013 Dec;50:153-9. doi: 10.1016/j.peptides.2013.10.015. PMID: 24172540 PMID24172540;30789695 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24172540/
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