Peptide Database

Peptide NameSLAY-screened peptide P5618

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC95H151N25O35S

DescriptionStandard

        VDPLTIQYKTDNATHASMET
    

Molecular Weight2235.43 Da

Isoelectric Point (pI)4.54

Net Charge (pH 7.0)-2.18

Net Charge (pH 7.4) -2.44

Charge Density (pH 7.0) -0.1088

GRAVY Index-0.66

Hydrophobic Moment 0.24

Boman Index-0.03

Instability Index-1.78

Aliphatic Index 63.50

Aromaticity 0.0500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 981.59

LogP -11.83

H-bond Donors 33.0

H-bond Acceptors 35.0

Rotatable Bonds 71.0

Heavy Atoms 156.0

Ring Count 3.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0098819 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/