Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length483 amino acids

Chemical FormulaC2395H3785N613O689S17

DescriptionStandard

        MARDPDNTLRWATLMVLAALGTAVTEATNPGIVVRITQKGLDYACQQGVAVLQKELEKITIPSFSGSFKIKYLGKGDYSFYSLVIREVQLPSSQIRLLPNEGLAFSVTNANVKISGKWKARKNFIKTSGNFDLSVEGISISAGLKLSCDPASGHSTVTCSSCRNHIDSVHLHVSGSQLGWLIQLFHNKIESSLQNAMNNKICEVVTSSVSSKLEPFFQTLPVTASIDNVAGIDYSLLAPPIATTETLDGQLKGEFFSLAHRSPPPFAPPALAFPADHDHMVYLGISDYFFNTAGLVYQQAGVLNLTLKDDMIPKESKIRLTTKFFGTLIPQVAKMFPNMNMEILIRASSPPYLTVSPAGLAFTPALEAQAFAVLPNSSLAPLFLLGMSANVSVEVGAMSDRLVGELDLDKLLLELKHSDIGPFSIELLQSIMNYVVPSIVLPKVNEKLQKGFPLPMPSRVQLYNLVLQPYQEFLLFGADVHYR
    

Molecular Weight52735.47 Da

Isoelectric Point (pI)6.80

Net Charge (pH 7.0)-0.64

Net Charge (pH 7.4) -1.54

Charge Density (pH 7.0) -0.0013

GRAVY Index0.14

Hydrophobic Moment 0.66

Boman Index0.16

Instability Index42.30

Aliphatic Index 101.95

Aromaticity 0.0849

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 36120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0268508 VERIFIED: NO

Provenance & Taxonomy

OrganismMolossus molossus (Pallas` mastiff bat) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria