Peptide Database

Peptide NameSLAY-screened peptide P5749

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC93H129N23O26

DescriptionStandard

        GSASPLPAGPFHAPPFNFSS
    

Molecular Weight1985.16 Da

Isoelectric Point (pI)6.74

Net Charge (pH 7.0)-0.15

Net Charge (pH 7.4) -0.41

Charge Density (pH 7.0) -0.0076

GRAVY Index-0.06

Hydrophobic Moment 0.15

Boman Index0.31

Instability Index91.36

Aliphatic Index 34.50

Aromaticity 0.1500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 724.96

LogP -8.95

H-bond Donors 22.0

H-bond Acceptors 27.0

Rotatable Bonds 50.0

Heavy Atoms 142.0

Ring Count 9.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0019945 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/