Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length380 amino acids

Chemical FormulaC1850H2964N472O538S14

DescriptionStandard

        MKFICCLLSLLALLPVTTGINPGVEVKLTQKGLEYGRQMGIASIQKKLSSIKLPDISGTEHVDPIGKVQYSLTGMQIVNLGLPTSALGLVPGTGVSLSIDNAFINIHGNWRVKYLRIIKDSGSFDLAVSALTIRTTIAVTSDETGRPAITMTSCTADVGSVKVKFHGGASWLYNLFSSFINKALRSALQKQICPLVAESIADVNPYLKTLNVEAKVDNYAEIEYSMVGSPVISNASVDIGLKGEFYNIGQHKETPFSPAPFSLPSQNTNMLYIGVSAFTINSAGFVYHSAGALILNVTDDMIPLSSPIRLNTKTFGTFIPQIAKMYPGLMMKLLVKTVKQPFITIQPNNVTVQSSGLVTAYAIQPNGTLSPLFDLNLVSH
    

Molecular Weight40875.07 Da

Isoelectric Point (pI)8.99

Net Charge (pH 7.0)5.99

Net Charge (pH 7.4) 5.34

Charge Density (pH 7.0) 0.0158

GRAVY Index0.25

Hydrophobic Moment 0.71

Boman Index0.20

Instability Index35.15

Aliphatic Index 105.42

Aromaticity 0.0763

Extinction Coeff. Reduced 28880.00

Extinction Coeff. Oxidized 29130.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0389346 VERIFIED: NO

Provenance & Taxonomy

OrganismTriplophysa tibetana [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence