Peptide Database

Peptide NameSLAY-screened peptide P448

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC77H117N23O29S2

DescriptionStandard

        FTQAREAPCTPDMSSDH
    

Molecular Weight1893.02 Da

Isoelectric Point (pI)4.54

Net Charge (pH 7.0)-2.16

Net Charge (pH 7.4) -2.43

Charge Density (pH 7.0) -0.1269

GRAVY Index-1.01

Hydrophobic Moment 0.31

Boman Index-0.19

Instability Index63.79

Aliphatic Index 11.76

Aromaticity 0.0588

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 837.83

LogP -11.81

H-bond Donors 29.0

H-bond Acceptors 30.0

Rotatable Bonds 57.0

Heavy Atoms 131.0

Ring Count 4.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0387493 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/