‹ ›
MYP_040680
← PREVIOUS NEXT → BACK
Basic Information
25(derived from FIV envelope glycoprotein )
Antimicrobial
Antiviral
Antiviral ▸ Anti-Retrovirus ▸ Anti-Lentivirus ▸ Anti-FIV
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Standard
20 amino acids
C95H136N26O31S2
Standard
Sequence
MRSSGDYGEVTGAWIEFGCH
Physicochemical Analysis
2202.38 Da
4.65
-2.42
-2.70
-0.1208
-0.33
0.35
0.12
54.85
39.00
0.1500
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
915.41
-9.75
34.0
32.0
69.0
154.0
5.0
19.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0053436 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-FIV Replication inhibition
Feline immunodeficiency virus (FIV) | fibroblastoid cells
16 μg/mL
% inhibition
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperInhibition of feline immunodeficiency virus infection in vitro by envelope glycoprotein synthetic peptides. | Lombardi S, Massi C, Indino E, La Rosa C, Mazzetti P, Falcone ML, Rovero P, Fissi A, Pieroni O, Bandecchi P, Esposito F, Tozzini F, Bendinelli M, Garzelli C. | Virology. 1996 Jun 15;220(2):274-84. | DOI:10.1006/viro.1996.0315 | PMID:8661378 PMID8661378 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8661378/
RECORD: Rec_0287767 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 8661378 PMID8661378 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8661378/
RECORD: Rec_0296810 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Feline immunodeficiency virus (FIV):inhibition of virus replication in Crandell feline kidney
27 %
Inhibition
PaperPubMed PMID: 8661378 PMID8661378 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8661378/
RECORD: Rec_0307243 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 60.0%, C 40.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0347371 VERIFIED: YES
Provenance & Taxonomy
Feline immunodeficiency virus [Virus]
Virus-derived peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
Feline immunodeficiency virus (Syncytium formation); CrFK
27 %
Syncytia assay
PaperInhibition of feline immunodeficiency virus infection in vitro by envelope glycoprotein synthetic peptides. | Lombardi S, Massi C, Indino E, La Rosa C, Mazzetti P, Falcone ML, Rovero P, Fissi A, Pieroni O, Bandecchi P, Esposito F, Tozzini F, Bendinelli M, Garzelli C. | Virology. 1996 | PMID:8661378 PMID8661378 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8661378/