Peptide Database

Peptide NameBrevinin-1-OR11

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length23 amino acids

Chemical FormulaC106H170N28O29S4

DescriptionStandard

        LAFVAGVAAEMMQHVYCAASKKC
    

Molecular Weight2428.91 Da

Isoelectric Point (pI)8.04

Net Charge (pH 7.0)0.83

Net Charge (pH 7.4) 0.54

Charge Density (pH 7.0) 0.0360

GRAVY Index0.80

Hydrophobic Moment 0.40

Boman Index0.29

Instability Index1.76

Aliphatic Index 80.87

Aromaticity 0.0870

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 905.09

LogP -7.27

H-bond Donors 33.0

H-bond Acceptors 35.0

Rotatable Bonds 79.0

Heavy Atoms 167.0

Ring Count 3.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0205414 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide; DSSP H 52.2%, E 0.0%, T 34.8%, C 13.0% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antibacterial Antimicrobial Antifungal Anti-Gram-positive Anti-Gram-negative

RECORD: Rec_0209659 VERIFIED: YES

Provenance & Taxonomy

OrganismOdorrana rotodora [Animal]

FamilyBrevinin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetBacillus pyocyaneus CMCCB 10104

Activity12.4 μg/mL

MethodMIC

RECORD: Rec_0211403 VERIFIED: YES

Provenance & Taxonomy

OrganismOdorrana rotodora [Animal]

FamilyBrevinin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetEscherichia coli ATCC 25922

Activity6.2 μg/mL

MethodMIC

RECORD: Rec_0212473 VERIFIED: YES

Provenance & Taxonomy

OrganismOdorrana rotodora [Animal]

FamilyBrevinin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide17-23

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

Targethuman red blood cells at the concentration of 50 μg/mL

Activity50 μg/mL

MethodHemolysis

RECORD: Rec_0226143 VERIFIED: YES

Provenance & Taxonomy

OrganismOdorrana rotodora [Animal]

FamilyBrevinin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide17-23

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic

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