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MYP_040679
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Basic Information
Brevinin-1-OR11
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
23 amino acids
C106H170N28O29S4
Standard
Sequence
LAFVAGVAAEMMQHVYCAASKKC
Physicochemical Analysis
2428.91 Da
8.04
0.83
0.54
0.0360
0.80
0.40
0.29
1.76
80.87
0.0870
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
905.09
-7.27
33.0
35.0
79.0
167.0
3.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0142577 VERIFIED: YES
Provenance & Taxonomy
Odorrana rotodora [Animal]
Brevinin
8292
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
17-23
Bio-Activity Profile
Antimicrobial
PaperExtremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs PMID22029824 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22029824/
RECORD: Rec_0147474 VERIFIED: YES
Provenance & Taxonomy
Odorrana rotodora [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
17-23
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Bacillus pyocyaneus CMCCB 10104
12.4 μg/mL
MIC
PaperExtremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. PMID: 22029824. PMID22029824 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22029824/
RECORD: Rec_0168220 VERIFIED: YES
Provenance & Taxonomy
Odorrana rotodora [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
17-23
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus
12.4 μg/mL
MIC
PaperExtremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs PMID22029824 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22029824/
RECORD: Rec_0202544 VERIFIED: YES
Provenance & Taxonomy
Odorrana rotodora [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
17-23
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus ATCC 25923
12.4 μg/mL
MIC
PaperExtremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. PMID: 22029824. PMID22029824 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22029824/
RECORD: Rec_0202638 VERIFIED: YES
Provenance & Taxonomy
Odorrana rotodora [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
17-23
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
5.11 μM
MIC
PaperX. Yang et al. / Journal of Proteome Research 11 (2012) 306-319. Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs PMID22029824 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22029824/
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