Peptide Database

Peptide NameStRIP14

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC98H125N21O32

DescriptionStandard

        DDESEWFSYHLSFFNSV
    

Molecular Weight2109.16 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-4.15

Net Charge (pH 7.4) -4.41

Charge Density (pH 7.0) -0.2439

GRAVY Index-0.57

Hydrophobic Moment 0.34

Boman Index0.09

Instability Index30.49

Aliphatic Index 40.00

Aromaticity 0.2941

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 866.83

LogP -7.25

H-bond Donors 30.0

H-bond Acceptors 29.0

Rotatable Bonds 64.0

Heavy Atoms 151.0

Ring Count 7.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0043461 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermFluorescein labeling

C-TermNone

Other ModsStapled: Ⓧ(4) and Ⓧ (8), Ⓧ(12) and Ⓧ (16) are cross-linked by hydrocarbon stapling

Bio-Activity Profile

Function

Anticancer Antimicrobial Antibacterial

PaperCromm PM, Spiegel J, Küchler P, Dietrich L, Kriegesmann J, Wendt M, Goody RS, Waldmann H, Grossmann TN. Protease-Resistant and Cell-Permeable Double-Stapled Peptides Targeting the Rab8a GTPase. ACS Chem Biol. 2016 Aug 19;11(8):2375-95. PMID27336832 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27336832/