Peptide Database

Peptide NameRecombinant hirudin

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition

Hemostasis ▸ Anticoagulant activity

Standard StatusStandard

Sequence Length65 amino acids

Chemical FormulaC287H446N80O110S6

DescriptionStandard

        VVYTDCTESGQNLCLCEGSNVCGQGNKCILGSDGEKNQCVTGEGTPKPQSHNDGDFEEIPEEYLQ
    

Molecular Weight6969.47 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-9.22

Net Charge (pH 7.4) -9.59

Charge Density (pH 7.0) -0.1418

GRAVY Index-0.77

Hydrophobic Moment 0.47

Boman Index-0.06

Instability Index48.15

Aliphatic Index 53.85

Aromaticity 0.0462

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3086.89

LogP -42.39

H-bond Donors 105.0

H-bond Acceptors 108.0

Rotatable Bonds 233.0

Heavy Atoms 483.0

Ring Count 7.0

Amide Bonds 74.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0201759 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyHirudin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Anticoagulant

MethodELISA

Half-LifeHuman blood sample, in vivo; 9000 s

RECORD: Rec_0372663 VERIFIED: YES

Provenance & Taxonomy

OrganismHirudo medicinalis [Animal]

Familyprotease inhibitor I14 (hirudin) family

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide6-14; 16-28; 22-39

Other Mods63-Tyr: Sulfotyrosine

Bio-Activity Profile

Function

Other protease inhibitor I14 (hirudin) family