Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length516 amino acids

Chemical FormulaC2523H3973N651O740S20

DescriptionStandard

        MLSLLILLLNLTNHAFGQNPAIKAILTNKGLQYGSHIGADWMQEKIGSVIIPDVSGGVDIGIGTVHYVLDGISVSGCDVPEPSVEFYEGVGLKAVISGLSISMSGNWHTRFGIITDGGSFDLAVFNVDVTSVVQIGSDQSGHISISSKNCDAKVGEASINFHGGASLIFQPFVSLFHHRIKAIIEERICPLVEEHVTDLERHLAEMQVSFKVNSALVLDVPLTNSPLVDSISLGLDLKGEFYSVQSHTDPPFKAEPFHLAEDKGHMLSLGLSEFTVNSASYAYFSAGLLQAQINDSMIPKASPFRLNTTSFGPLIPQLPKLFPNMLMELQVYARDVPMFSFQADKVTMEFPGAVKAFAIQPNASRTPLFKLNVDSIFSGMIRISEEKLNGLVELSNFTLTLASSEVGTFQTAALEKFMKLGMKISVLAKLNAKLEEGIVLPTMHHIHLVNPALKIQQGFVSIASDLDVKSGEGENLSEGIYHYRLCGVEKIPPCQNPPPLHVNAHTLNSSLLQLAC
    

Molecular Weight55906.75 Da

Isoelectric Point (pI)5.59

Net Charge (pH 7.0)-14.83

Net Charge (pH 7.4) -16.21

Charge Density (pH 7.0) -0.0287

GRAVY Index0.18

Hydrophobic Moment 0.68

Boman Index0.19

Instability Index32.56

Aliphatic Index 103.14

Aromaticity 0.0756

Extinction Coeff. Reduced 24410.00

Extinction Coeff. Oxidized 24785.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0420943 VERIFIED: NO

Provenance & Taxonomy

OrganismOncorhynchus tshawytscha [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence