Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length456 amino acids

Chemical FormulaC2245H3620N582O632S20

DescriptionStandard

        MFLCCWLALVALIPTTVSINPGVKVKLTEKGLEYGRDLGMATIQQKLKTIKVPDMSGEQRVSPIGKVHYSLTNMHIVNVGLPKSAVDLVPGTGVRLSITNAFISLQGNWRVKYLRIIKDSGSFDLNVNGLTITSSIAIKSDETGRPAVSSVNCAATVSKASIKFHGGASWLYNLFSKFIDKALRNALQNKICPLVADAISDLNPHLKTLNGKTFSLCQILGCFIDSWHNLSFHQEPPFSPKPFTLAPQINNMLYIGVSAFTTNSAAFVYNKAGALSLAITDDMIPQSSPIRLNTRTFGAFIPQIAKRFPGLMMKLLVKTVKDPIITFETNNMTVQAIGTVTAYAIQPNATLSPLFVLNMDTSVSARVYVSGVKLAGAVTLNKMDLTLGTSYVGDFQVGSLDNILQMVLKVVVIPKLNVQLAKGYPLPTLGKMKLVNTQLQVLKDYMLIGTDVQFTG
    

Molecular Weight49517.58 Da

Isoelectric Point (pI)9.60

Net Charge (pH 7.0)17.96

Net Charge (pH 7.4) 17.26

Charge Density (pH 7.0) 0.0394

GRAVY Index0.25

Hydrophobic Moment 0.84

Boman Index0.17

Instability Index30.09

Aliphatic Index 106.01

Aromaticity 0.0768

Extinction Coeff. Reduced 38390.00

Extinction Coeff. Oxidized 38765.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0179897 VERIFIED: NO

Provenance & Taxonomy

OrganismDicentrarchus labrax [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence