Peptide Database

Peptide NametagU signal peptide

Function Ontology

Annotation / Sequence feature ▸ Signal peptide

Biotechnology / Production and expression ▸ Secretory enzyme production ▸ Cutinase secretion

Biotechnology / Production and expression ▸ Secretory expression optimization

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC210H349N57O50S

DescriptionStandard

        MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAA
    

Molecular Weight4504.43 Da

Isoelectric Point (pI)10.45

Net Charge (pH 7.0)6.58

Net Charge (pH 7.4) 6.30

Charge Density (pH 7.0) 0.1688

GRAVY Index0.08

Hydrophobic Moment 0.44

Boman Index0.06

Instability Index54.68

Aliphatic Index 125.13

Aromaticity 0.1026

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 9970.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1751.39

LogP -9.44

H-bond Donors 65.0

H-bond Acceptors 59.0

Rotatable Bonds 154.0

Heavy Atoms 318.0

Ring Count 6.0

Amide Bonds 39.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0389006 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus subtilis [Bacterium]

FamilySec signal peptide

Tax ID1423

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization Cutinase secretion

TargetBacillus subtilis TEB1030

MethodSecretion phenotype assay

PaperBrockmeier U, Caspers M, Freudl R, et al. Systematic screening of all signal peptides from Bacillus subtilis: A powerful strategy in optimizing heterologous protein secretion in gram-positive bacteria[J]. Journal of Molecular Biology, 2006, 362(3): 393-402. PMID16930615 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16930615/