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MYP_040515
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Basic Information
White cloud bean defensin
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
75 amino acids
C372H579N109O108S11
Standard
Sequence
MEKKSFAGLCFLFLVLFVAQECVLQTEAKTCENLADTFRGPCFATGNCDDHCKNKEHLLRGRCRDDFRCWCTRNC
Physicochemical Analysis
8658.96 Da
7.49
0.59
0.11
0.0079
-0.25
0.63
-0.10
31.84
59.87
0.1067
5500.00
6125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3535.50
-36.00
133.0
122.0
289.0
600.0
12.0
80.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0005440 VERIFIED: YES
Provenance & Taxonomy
Phaseolus vulgaris [Plant]
Knottin
3885
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Antiviral Cytotoxic
Human breast adenocarcinoma MCF-7
5.7 μM
IC50
PMID16687191 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16687191/
RECORD: Rec_0034385 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
Disulfide linkage reported
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial Antifungal
Mycobacterium phlei
6 μM
IC50
PMID16687191 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16687191/
RECORD: Rec_0036105 VERIFIED: YES
Provenance & Taxonomy
Phaseolus vulgaris [Plant]
Knottin
3885
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Antiviral Cytotoxic Anti-Gram-positive
Staphylococcus aureus
PMID16687191 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16687191/
RECORD: Rec_0107257 VERIFIED: YES
Provenance & Taxonomy
Phaseolus vulgaris [Plant]
Knottin
3885
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Antiviral Cytotoxic
Mycosphaerella arachidicola
0.72±0.02 μM
IC50
PMID16687191 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16687191/
RECORD: Rec_0110938 VERIFIED: YES
Provenance & Taxonomy
Phaseolus vulgaris [Plant]
Knottin
3885
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Antiviral Cytotoxic
Mycosphaerella arachidicola
1.3±0.04 μM
IC50
PMID16687191 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16687191/
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