Peptide Database

Peptide Namegamma-gliadin 1380 (p111-p130; E112, E119, E121 and E126) ; gamma-gliadin M12 M36999 (111-130) homologous to DQ2-gamma-IV

Function Ontology

Immunology ▸ Immunomodulation ▸ Celiac-immunogenic

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC108H153N27O36

DescriptionStandard

        PEQPFPQPEQEFPQPEQPQQ
    

Molecular Weight2405.53 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-4.03

Net Charge (pH 7.4) -4.09

Charge Density (pH 7.0) -0.2015

GRAVY Index-2.21

Hydrophobic Moment 0.41

Boman Index-0.28

Instability Index180.02

Aliphatic Index 0.00

Aromaticity 0.1000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1000.32

LogP -10.13

H-bond Donors 26.0

H-bond Acceptors 32.0

Rotatable Bonds 70.0

Heavy Atoms 171.0

Ring Count 9.0

Amide Bonds 26.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0199252 VERIFIED: YES

Provenance & Taxonomy

OrganismTriticum aestivum [Plant]

FamilyGliadin

Tax ID4565

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsDeamidation; Reported substitutions/positions: E112,E119,E121; Reported substitutions/positions: E126; Reported substitutions/positions: M12; Reported substitutions/positions: M36999

Bio-Activity Profile

Function

Celiac-immunogenic

TargetHuman intestinal T cells / HLA-DQ2

MethodT-cell proliferation assay