MYP_040479
Beta-defensin 2(BD-2, hBD-2, SAP1)
Antimicrobial
Standard
45 amino acids
C205H340N60O56S6
Standard
GIGDPVTCLKSGAICANTIHPVFCPRRYKQIGTCGLPGTKCCKKP
4733.65 Da
9.30
5.78
5.43
0.1285
-0.05
0.52
0.04
33.03
69.33
0.0444
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
1827.21
-20.28
68.0
69.0
150.0
327.0
8.0
46.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0037231
VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
8-37, 15-30, 20-38
Bio-Activity Profile
Antimicrobial
HIV-1 BaL:inhibition of viral infection in TZM-bl cells , 68% Inhibition at 50 μg/ml, 55% Inhibition at 25 μg/ml, 45% Inhibition at 12.5 μg/ml, 32% Inhibition at 6.2 μg/ml, 28% Inhibition at 3.1 μg/ml, 18% Inhibition at 1.6 μg/ml, 20% Inhibition at 0.8 μg/ml
80 %
Inhibition
RECORD: Rec_0273401
VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
8-37, 15-30, 20-38
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0360824
VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
8-37, 15-30, 20-38
Bio-Activity Profile
Antimicrobial
HIV-1 IIIB:inhibition of viral infection in TZM-bl cells , 87% Inhibition at 50 μg/ml, 75% Inhibition at 25 μg/ml, 62% Inhibition at 12.5 μg/ml, 55% Inhibition at 6.2 μg/ml, 35% Inhibition at 3.1 μg/ml, 28% Inhibition at 1.6 μg/ml, 25% Inhibition at 0.8 μg/ml
95 %
Inhibition