MYP_040450
Agalsidase alfa
Therapeutic / Biomedical activity
▸
Enzyme replacement therapy
Standard
398 amino acids
C2029H3080N544O587S27
Standard
LDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENTMQMSLKDLL
45351.21 Da
5.17
-10.70
-11.53
-0.0269
-0.31
0.74
0.04
42.35
79.45
0.1156
110350.00
111100.00
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Amino Acid Composition
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0259960
VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Enzyme
9606
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Lipidation
Bio-Activity Profile
Enzyme replacement
The elimination half life was 108 ± 17 minutes for males and 89 ± 28 minutes for females.[L16398]
RECORD: Rec_0319853
VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]; Cricetulus griseus [Animal]
Enzyme
9606;10029
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
Lipidation
Bio-Activity Profile
Enzyme replacement
CHO
67 ± 12 min for a 1 mg/kg dose (mean infusion length = 115 minutes.)