Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length483 amino acids

Chemical FormulaC2405H3830N636O669S14

DescriptionStandard

        MAREPDSALRWAALLVLATLGTAVMAATNPGVVARITQKGLDYACQQGVAVLQKELEKIKIPDFSGSFKIKHLGKGHYSFYSMVIRRFQLPSSQIRLVPNKGLDLSIRNANVKISGKWKARKKFIKTKGNFDLGVEGISISAGLELGFDPASGLPTATCSSCSNHIKSVSVHISGGKLGWLIQLFHKKIESSIRKTMSSKICQIVTSSVSSKLQSYLKTLRVTTKIDEVSGINYSLVAAPTATANNLDWQLKGEFFSVAHPSPPPFTSPALDFPANHDRMVYLGISDYFFNTAGLVYQQAGVLHLTITDNMIPKRSKFRLTTTSLGTLIPQVAKMFPNMPVQFNIWASSPPHLTVLPTGLVFTPALEIQAFAVLPNSSLASLFVLHLNTNASMEVNATADRLVGKLSLDTLLLELKHSDVGPFSVVVLQAIMNYVLPLTVIPRINERLEEGFPLPLPANIRLFNLVLQSHQNFVLFGADVHYG
    

Molecular Weight52806.91 Da

Isoelectric Point (pI)9.66

Net Charge (pH 7.0)17.61

Net Charge (pH 7.4) 16.59

Charge Density (pH 7.0) 0.0365

GRAVY Index0.15

Hydrophobic Moment 0.70

Boman Index0.15

Instability Index40.48

Aliphatic Index 103.15

Aromaticity 0.0828

Extinction Coeff. Reduced 42400.00

Extinction Coeff. Oxidized 42650.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0173105 VERIFIED: NO

Provenance & Taxonomy

OrganismNeomonachus schauinslandi [Animal]

FamilyBPI

Tax ID29088

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence