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MYP_040264
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Basic Information
JEV Ep (401428)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Japanese encephalitis virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
28 amino acids
C129H203N35O40
Standard
Sequence
STLGKAFSTTLKGAQRLAALGDTAWDFG
Physicochemical Analysis
2884.20 Da
8.31
0.46
0.25
0.0164
0.00
0.62
0.13
-10.55
73.57
0.1071
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1217.82
-14.25
44.0
41.0
94.0
204.0
4.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0110566 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Japanese encephalitis virus (JEV)
PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/
RECORD: Rec_0259936 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Japanese encephalitis virus (JEV):inhibition of JEV infection in BHK-21 (baby hamster kidney) cells
3.79071 μM
IC50
PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/
RECORD: Rec_0369143 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Baby Hamster Kidney cells BHK-21
25 % Cell death
Cell death
PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/
RECORD: Rec_0425898 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-JEV Entry inhibition
Japanese encephalitis virus (JEV)
3.791 μM
IC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperAntiviral activity of peptide inhibitors derived from the protein E stem against Japanese encephalitis and Zika viruses. | Chen L, Liu Y, Wang S, Sun J, Wang P, Xin Q, Zhang L, Xiao G, Wang W. | Antiviral Res. 2017 May;141:140-149. | DOI:10.1016/j.antiviral.2017.02.009 | PMID:28232248 PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/