Peptide Database

Peptide NameProtegrin-3 (PG-3)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Listeria

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length149 amino acids

Chemical FormulaC720H1173N211O217S10

DescriptionStandard

        METQRASLCLGRWSLWLLLLALVVPSASAQALSYREAVLRAVDRLNEQSSEANLYRLLELDQPPKADEDPGTPKPVSFTVKETVCPRPTRQPPELCDFKENGRVKQCVGTVTLDQIKDPLDITCNEVQGVRGGGLCYCRRRFCVCVGRG
    

Molecular Weight16577.95 Da

Isoelectric Point (pI)8.08

Net Charge (pH 7.0)1.44

Net Charge (pH 7.4) 1.06

Charge Density (pH 7.0) 0.0097

GRAVY Index-0.28

Hydrophobic Moment 0.77

Boman Index-0.08

Instability Index37.85

Aliphatic Index 88.25

Aromaticity 0.0537

Extinction Coeff. Reduced 15470.00

Extinction Coeff. Oxidized 15970.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6900.58

LogP -71.98

H-bond Donors 247.0

H-bond Acceptors 229.0

Rotatable Bonds 544.0

Heavy Atoms 1158.0

Ring Count 21.0

Amide Bonds 160.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0108320 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyCathelicidin

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Antilisterial Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetListeria monocytogenes (Gram-positive)

RECORD: Rec_0211792 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyCathelicidin

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Antilisterial Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetCandida albicans

RECORD: Rec_0372569 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyCathelicidin

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Antilisterial Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetEscherichia coli (Gram-negative)