Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length187 amino acids

Chemical FormulaC925H1463N253O248S9

DescriptionStandard

        PMALATAHEPMLLLAVTEFVANSAAFTYFTAGALRRNISSSMIPRRFPLQLTTKSMGVFSPQLQERYPDQPMELHLSARWQPLLSCHPDGLHGALFGSAEAFVVLPNATRVPAFLLNIDANVTGKPTITGNRLRGTVSLTGPLCLCRAGLRGLPVLQVKRLETLLKFGLWLFGVPWANSESCPHPVP
    

Molecular Weight20384.64 Da

Isoelectric Point (pI)9.62

Net Charge (pH 7.0)6.37

Net Charge (pH 7.4) 5.98

Charge Density (pH 7.0) 0.0341

GRAVY Index0.18

Hydrophobic Moment 0.60

Boman Index0.15

Instability Index54.90

Aliphatic Index 97.06

Aromaticity 0.0802

Extinction Coeff. Reduced 19480.00

Extinction Coeff. Oxidized 19730.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7829.53

LogP -89.70

H-bond Donors 273.0

H-bond Acceptors 268.0

Rotatable Bonds 641.0

Heavy Atoms 1435.0

Ring Count 41.0

Amide Bonds 199.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0402530 VERIFIED: NO

Provenance & Taxonomy

OrganismGrus americana [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria