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MYP_040069
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Basic Information
Corticoliberin
Antimicrobial
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Cardiovascular
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Stress-related neuropeptide
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Neurological / Signaling ▸ Sleep regulation
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
41 amino acids
C208H343N59O64S2
Standard
Sequence
SEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII
Physicochemical Analysis
4758.44 Da
5.09
-3.35
-3.67
-0.0817
-0.26
0.77
-0.03
52.47
111.95
0.0244
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1993.20
-16.71
67.0
65.0
163.0
333.0
5.0
44.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0355734 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Corticoliberin
9823
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Reproductive regulator Growth regulation Development regulation
from pituitary gland
Experimental: 30.5±3.3 minutes; /1830 seconds; Mammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Corticoliberin (Sus scrofa): PMID 3878520##1319455 PMID3878520;1319455 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3878520/
RECORD: Rec_0358069 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]; Mus musculus [Animal]; Rattus norvegicus [Animal]
9606; 10090; 10116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Bio-Activity Profile
-
RECORD: Rec_0365376 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0422307 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hormone-derived peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antitrypanosomal
Trypanosoma brucei clone 221 (procyclic form)
LD50; MTT assay
PaperNeuropeptides kill African trypanosomes by targeting intracellular compartments and inducing autophagic-like cell death PMID19057622 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19057622/
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