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MYP_040069
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Basic Information
Corticoliberin
Antimicrobial
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Cardiovascular
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Stress-related neuropeptide
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Neurological / Signaling ▸ Sleep regulation
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Standard
41 amino acids
C208H343N59O64S2
Standard
Sequence
SEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII
Physicochemical Analysis
4758.44 Da
5.09
-3.35
-3.67
-0.0817
-0.26
0.77
-0.03
52.47
111.95
0.0244
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1993.20
-16.71
67.0
65.0
163.0
333.0
5.0
44.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0008426 VERIFIED: YES
Provenance & Taxonomy
Canis lupus familiaris [Animal]
Corticoliberin
9615
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator
intestinal epithelial cells
Experimental: 30.5±3.3 minutes; /1830 seconds; Mammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Corticoliberin (Canis lupus familiaris): PMID 7969821##1319455 PMID7969821;1319455 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7969821/
RECORD: Rec_0009933 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
sauvagine/corticotropin-releasing factor/urotensin I family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone sauvagine corticotropin-releasing factor urotensin I family
PaperPDB 3EHU structural record; X-ray; 1.96 A; chain C/D; residues 22-41
RECORD: Rec_0040224 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Neurotransmitter
IRM(Immunoradiometric assays)
Human plasma, in vivo; 2790 s
PMID1319455 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1319455/
RECORD: Rec_0050243 VERIFIED: YES
Provenance & Taxonomy
Rattus norvegicus [Animal]
Corticoliberin
10116
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Analgesic Pronociceptive Hormone Endocrine Neuropeptide Neuromodulator Cardiovascular Metabolic regulation Physiological regulation Reproductive regulator Growth regulation Development regulation Receptor modulation
from pituitary gland
Experimental: 30.5±3.3 minutes; /1830 seconds; Mammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Corticoliberin (Rattus norvegicus): PMID 1319455 PMID1319455 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1319455/
RECORD: Rec_0058338 VERIFIED: YES
Provenance & Taxonomy
Ovis aries [Animal]
GHRH/CRF
9940
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
ACTH release stimulation
Radioimmunoassay
Rhesus monkey plasma, in vivo; 2658 s
PMID2988919 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2988919/
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