MYP_039950
H-58
Anticancer
Toxicity / Safety
▸
Blood cell toxicity
▸
Hemolysis
▸
Hemolytic
Standard
29 amino acids
C143H268N40O33S
Standard
IKLSKKTKKNLKKVLKGAIKGAIAVAKMV
3107.97 Da
10.95
9.75
9.53
0.3362
0.06
0.69
-0.05
-8.38
124.48
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
1221.87
-8.15
43.0
44.0
119.0
217.0
0.0
29.0
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
RECORD: Rec_0377697
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Hymenochirin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The S (position: 4), T (position: 7) and N (position: 10) in sequence are linked with N-acetylglucosamine (GlcNAc), respectively. The Ⓧ (position: 18 and 22) indicate (S)-N-Fmoc-2-(4'-pentenyl)alanine. Ⓧ (18) and Ⓧ (22) are cross-linked by ring-closing metathesis through an oct-4-enyl hydrocarbon staple, respectively
Bio-Activity Profile
Hemolytic
fresh rabbit blood cells
0.010 μM
Hemolysis
RECORD: Rec_0396416
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Hymenochirin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
The Ⓧ (position: 18 and 22) in sequence indicate (S)-N-Fmoc-2-(4'-pentenyl)alanine. Ⓧ (18) and Ⓧ (22) are cross-linked by ring-closing metathesis through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Hemolytic
fresh rabbit blood cells
0.010 μM
Hemolysis
Showing 2 records on this page · Page 6 of 6