Peptide Database

Peptide NameCPEM

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length7 amino acids

Chemical FormulaC38H59N7O10S2

DescriptionStandard

        CPEVFLM
    

Molecular Weight838.05 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.25

Net Charge (pH 7.4) -1.47

Charge Density (pH 7.0) -0.1781

GRAVY Index1.44

Hydrophobic Moment 0.19

Boman Index0.52

Instability Index60.91

Aliphatic Index 97.14

Aromaticity 0.1429

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 266.43

LogP 0.31

H-bond Donors 9.0

H-bond Acceptors 11.0

Rotatable Bonds 24.0

Heavy Atoms 57.0

Ring Count 2.0

Amide Bonds 6.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0344414 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermCyclization

C-TermCyclization

Bio-Activity Profile

Function

Antimicrobial Antiviral

Targetinhibition of cell-cell fusion between H9/HIV-1IIIB cells and MT-2 cells

Activity200 μM

MethodIC50

RECORD: Rec_0423381 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configcyclic peptide architecture [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermCyclization (N termini to C termini)

C-TermCyclization (N termini to C termini)

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

Targetinhibition of cell-cell fusion between H9/HIV-1IIIB cells and MT-2 cells

Activity200 μM

MethodIC50

Half-LifeMammalian: 1.2 h; Yeast: >20 h; E. coli: >10 h

PaperShort cyclic peptides derived from the C-terminal sequence of α1-antitrypsin exhibit significant anti-HIV-1 activity. | Jia Q, Jiang X, Yu F, Qiu J, Kang X, Cai L, Li L, Shi W, Liu S, Jiang S, Liu K. | Bioorg Med Chem Lett. 2012 Apr 1;22(7):2393-5. | DOI:10.1016/j.bmcl.2012.02.037 | PMID:22406118 PMID22406118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22406118/

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