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MYP_039877
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Basic Information
KF4
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Lactocepin Inhibitor
Hormonal / Endocrine ▸ Hormone peptide
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
2 amino acids
C11H20N2O3
Standard
Sequence
LP
Physicochemical Analysis
228.29 Da
5.53
-0.24
-0.44
-0.1200
1.10
0.52
0.59
101.30
195.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
83.63
0.44
2.0
3.0
4.0
16.0
1.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0325214 VERIFIED: YES
Provenance & Taxonomy
marine natural metabolite [other]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
Lactam
Lactam
Lactam
Bio-Activity Profile
Antimicrobial Anticancer
MDA-MB-231
73.4 μM
IC50
PaperPubMed PMID: 31669320 PMID31669320 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31669320/
RECORD: Rec_0350776 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antihypertensive
PaperAHTPDB: a comprehensive platform for analysis and presentation of antihypertensive peptides PMID25392419 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25392419/
RECORD: Rec_0359150 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic peptide topology [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus
PMID28512456 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28512456/
RECORD: Rec_0387743 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]; Lysteria monocytogenes [Animal]; Amaranthus hypochondriacus [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone Transporter Enzyme inhibitory Taste ACE inhibitory
Angiotensin-converting enzyme
337320 μM
IC50
RECORD: Rec_0424887 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Serum albumin-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
DPP-IV inhibitory Antidiabetic
Dipeptidyl peptidase-IV (DPP-IV)
712.5 μM
IC50
PaperInhibition of dipeptidyl peptidase IV (DPP-IV) by proline containing casein-derived peptides | Nongonierma, A. et al. | DOI: 10.1016/j.jff.2013.09.012 Evidence URLhttps://www.uniprot.org/uniprotkb/P02769/entry
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