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MYP_039850
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Basic Information
Amphiphatic peptide CT2 (VmCT2; Non-disulfide-bridged peptide 5.14, NDBP-5.14; Arthropods, animal
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
13 amino acids
C73H108N16O18
Standard
Sequence
FLSTLWNAAKSIF
Physicochemical Analysis
1497.73 Da
8.75
0.76
0.55
0.0584
0.82
0.52
0.40
36.94
105.38
0.2308
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
558.11
-3.03
20.0
19.0
46.0
107.0
4.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0297139 VERIFIED: YES
Provenance & Taxonomy
Vaejovis mexicanus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Streptococcus agalactiae (clinical isolate)
20 μM
MIC
PMID22342498 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22342498/
RECORD: Rec_0305219 VERIFIED: YES
Provenance & Taxonomy
Mexican scorpion [Animal]; Arthropoda [Animal]
33208; 6656
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID22342498 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22342498/
RECORD: Rec_0308604 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0308994 VERIFIED: YES
Provenance & Taxonomy
Vaejovis mexicanus smithi [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
S. typhi ATCC 6399
5 μM
MIC
PaperGene cloning and functional characterization of four novel antimicrobial-like peptides from scorpions of the family Vaejovidae.
RECORD: Rec_0320188 VERIFIED: YES
Provenance & Taxonomy
Vaejovis mexicanus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis ATCC 6633
20 μM
MIC
PMID22342498 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22342498/
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