Peptide Database

Peptide NameAtrial natriuretic peptide-45

Function Ontology

Cardiovascular

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Regulatory peptide ▸ Cell-cell communication

Standard StatusStandard

Sequence Length45 amino acids

Chemical FormulaC213H351N71O65S3

DescriptionStandard

        SQDSAFRIQERLRNSKMAHSSSCFGQKIDRIGAVSRLGCDGLRLF
    

Molecular Weight5042.70 Da

Isoelectric Point (pI)10.07

Net Charge (pH 7.0)3.53

Net Charge (pH 7.4) 3.24

Charge Density (pH 7.0) 0.0785

GRAVY Index-0.44

Hydrophobic Moment 0.74

Boman Index-0.19

Instability Index65.22

Aliphatic Index 73.78

Aromaticity 0.0667

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2259.01

LogP -28.66

H-bond Donors 84.0

H-bond Acceptors 73.0

Rotatable Bonds 176.0

Heavy Atoms 352.0

Ring Count 4.0

Amide Bonds 48.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0033158 VERIFIED: NO

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

Tax ID10116

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide23-39

Bio-Activity Profile

Function

Neuropeptide

RECORD: Rec_0196775 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyNatriuretic peptide

Tax ID10116

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide23-39

Bio-Activity Profile

Function

Natriuretic

MethodRadioimmunoassay

Half-Life(Dose i/v injected)Mice (WKY) plasma, in vivo; 417 s

RECORD: Rec_0292937 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Cell-Cell Communication

RECORD: Rec_0352721 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyNatriuretic peptide

Tax ID10116

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide23-39

Bio-Activity Profile

Function

Hormone Cardiovascular

RECORD: Rec_0386762 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyBrain natriuretic peptide

Tax ID10116

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide23-39

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Cardiovascular Growth regulation Development regulation Receptor modulation

Half-LifeExperimental: 45 (t1/2 alpha or initial phase t1/2) seconds; /45 seconds; Mammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour