Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length487 amino acids

Chemical FormulaC2529H4043N653O672S16

DescriptionStandard

        WCYCDSQAKRMRTATLILALFTVFVVTAWANNPGLVARITDKGIDYARVKGIQSLQKALTKIKIPDFTGKFRIKHFLKVHYSFYNIIIRNFQLPSSSITLVPGTGLKVSIQNAFIELNGQWRVKMKIMRTHGSFRVNVKGLSASVGLKLGADGSGRPTVSTFSCSSHISAVKVHISGRLSWLYKIFKKSIESRLRKSLENKMCSVIQKSITEKLQPILQTLKVTAKVDKYAGINYSLVSPPTITSVSLDLGLKGEFFDLFHHVKIPFDASALNIPLGQNRMLYFGLSKYFFNSAGFIYHAVGALVKNITDDMIPKESKIRLNTTYFGLLIPQVYKILCNLYIYIYIYIYVPPPLNCSKETLKFTHQKRKDSSIILILPSELLKMSTKIFKKNTSILAKIGVVDNRITAKVNLDRLQMTLKHSDVGTFSVSVLNIAINFCVSWILLPEVNDLLAKGYPLPVMDHIKLSDITIEPKQNFLLFGANVIYN
    

Molecular Weight54861.17 Da

Isoelectric Point (pI)9.90

Net Charge (pH 7.0)36.63

Net Charge (pH 7.4) 35.64

Charge Density (pH 7.0) 0.0752

GRAVY Index0.15

Hydrophobic Moment 0.73

Boman Index0.12

Instability Index34.14

Aliphatic Index 109.06

Aromaticity 0.1027

Extinction Coeff. Reduced 55810.00

Extinction Coeff. Oxidized 56185.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0395165 VERIFIED: NO

Provenance & Taxonomy

OrganismLatimeria chalumnae [Animal]

FamilyBPI/LBP

Tax ID7897

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria