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MYP_039686
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Basic Information
5
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
16 amino acids
C73H123N17O20
Standard
Sequence
GLFDVIKAVASVIGGL
Physicochemical Analysis
1558.86 Da
5.84
-0.24
-0.44
-0.0150
1.64
0.54
0.59
19.49
164.38
0.0625
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
583.37
-3.40
20.0
20.0
51.0
110.0
1.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0216847 VERIFIED: YES
Provenance & Taxonomy
Ranoidea aurea [Animal]
Amphibian skin peptides
8371.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antimicrobial
Skin cancer cells
>100 μM
IC50
PapernNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1; The solution structure and activity of caerin 1.1, an antimicrobial peptide from the Australian green tree frog, Litoria splendida | https://pubmed.ncbi.nlm.nih.gov/12631273/ PMID12631273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12631273/
RECORD: Rec_0220139 VERIFIED: YES
Provenance & Taxonomy
Amphibian skin [Animal]
Citropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Ovarian cancer group (NCI)
10 μM
IC50
PapernNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1. Eur J Biochem. 2003 Mar;270(6):1141-1153. doi: 10.1046/j.1432-1033.2003.03462.x. PMID: 12631273. PMID12631273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12631273/
RECORD: Rec_0226031 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Citropin / Aurein-like peptide family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
RECORD: Rec_0273371 VERIFIED: YES
Provenance & Taxonomy
Amphibian skin [Animal]
Citropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Prostate cancer group (NCI)
10 μM
IC50
PapernNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1. Eur J Biochem. 2003 Mar;270(6):1141-1153. doi: 10.1046/j.1432-1033.2003.03462.x. PMID: 12631273. PMID12631273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12631273/
RECORD: Rec_0278218 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Amphibian skin secretions
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
Skin tumor cell line
>100 μM
IC50
PapernNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1 PMID12631273;9266696 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12631273/
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