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MYP_039669
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Basic Information
7R-Ahx-HBV Large envelope protein (19-24)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HBV
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
14 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
RRRRRRRXLDPAFR
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0327767 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 8
Bio-Activity Profile
Antiviral
Human hepatocellular carcinoma HepG2.2.15
556.8
IC50
PMID21144865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144865/
RECORD: Rec_0328464 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
The 'X' at position 8 is 6-aminocaproic acid.
Bio-Activity Profile
Antiviral Anti-HBV
HBV
10.9±3.4 μM
EC90
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperArtificial recombinant cell-penetrating peptides interfere with envelopment of hepatitis B virus nucleocapsid and viral production. | Pan XB, Wei L, Han JC, Ma H, Deng K, Cong X. | Antiviral Res. 2011 Jan;89(1):109-14. | DOI:10.1016/j.antiviral.2010.12.001 | PMID:21144865 PMID21144865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144865/
RECORD: Rec_0344097 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
The 'X' at position 8 is 6-aminocaproic acid.
Bio-Activity Profile
Antiviral Anti-HBV
HBV | of cell; HepG2.2.15 cells
3±1 μM
EC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperArtificial recombinant cell-penetrating peptides interfere with envelopment of hepatitis B virus nucleocapsid and viral production. | Pan XB, Wei L, Han JC, Ma H, Deng K, Cong X. | Antiviral Res. 2011 Jan;89(1):109-14. | DOI:10.1016/j.antiviral.2010.12.001 | PMID:21144865 PMID21144865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144865/
RECORD: Rec_0361355 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
The 'X' at position 8 is 6-aminocaproic acid
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PMID21144865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144865/
RECORD: Rec_0375610 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
The 'X' at position 8 is 6-aminocaproic acid
Bio-Activity Profile
Antimicrobial Antiviral
PMID21144865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21144865/
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