Peptide Database

Peptide NameMHV (1096-1117)[Y1117W]

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length22 amino acids

Chemical FormulaC125H174N30O30

DescriptionStandard

        GNHILSLVQNAPYGLYFIHFSW
    

Molecular Weight2576.90 Da

Isoelectric Point (pI)6.92

Net Charge (pH 7.0)-0.07

Net Charge (pH 7.4) -0.37

Charge Density (pH 7.0) -0.0031

GRAVY Index0.35

Hydrophobic Moment 0.50

Boman Index0.40

Instability Index40.20

Aliphatic Index 106.36

Aromaticity 0.2273

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 948.97

LogP -4.71

H-bond Donors 32.0

H-bond Acceptors 32.0

Rotatable Bonds 76.0

Heavy Atoms 185.0

Ring Count 9.0

Amide Bonds 24.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0305602 VERIFIED: YES

Provenance & Taxonomy

OrganismMurine coronavirus (Mouse hepatitis virus) [Virus]

FamilyVirus-derived peptide

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Fusion inhibitor

TargetMurine hepatitis virus (Fusion); L2

MethodPlaque assay

PaperInhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein. | Sainz B Jr, Mossel EC, Gallaher WR, Wimley WC, Peters CJ, Wilson RB, Garry RF. | Virus Res. 2006 | PMID:16616792 PMID16616792 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16616792/

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