Peptide Database

Peptide NameSLAY-screened peptide P5126

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC97H145N23O33S

DescriptionStandard

        CVYGDSQHLSVSDPDPFTLI
    

Molecular Weight2193.39 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-3.16

Net Charge (pH 7.4) -3.43

Charge Density (pH 7.0) -0.1580

GRAVY Index0.03

Hydrophobic Moment 0.13

Boman Index0.18

Instability Index22.84

Aliphatic Index 87.50

Aromaticity 0.1000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 883.46

LogP -9.16

H-bond Donors 30.0

H-bond Acceptors 32.0

Rotatable Bonds 65.0

Heavy Atoms 154.0

Ring Count 5.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0107765 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/