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MYP_039563
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Basic Information
MERS-CoV-HR2P [T1263E,L1267R]
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
36 amino acids
C186H308N46O62S
Standard
Sequence
SLTQINTTLLDLEYEMRSLQQVVKALNESYIDLKEL
Physicochemical Analysis
4212.77 Da
4.36
-3.53
-3.75
-0.0981
-0.18
0.78
0.00
27.79
127.22
0.0556
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1796.85
-15.59
61.0
60.0
147.0
295.0
2.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0061886 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of MERS-CoV infection in HFL cells
13.9 μM
IC50
PMID24473083 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24473083/
RECORD: Rec_0063723 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of MERS-CoV infection in Calu-3 cells
0.6 μM
IC50
PMID24473083 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24473083/
RECORD: Rec_0076893 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-MERS-CoV Fusion inhibition
MERS-COV (Middle East respiratory syndrome coronavirus) | 293T/MERS/EGFP cells
0.93±0.15 μM
IC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperStructure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor. | Lu L, Liu Q, Zhu Y, Chan KH, Qin L, Li Y, Wang Q, Chan JF, Du L, Yu F, Ma C, Ye S, Yuen KY, Zhang R, Jiang S. | Nat Commun. 2014;5:3067. | DOI:10.1038/ncomms4067 | PMID:24473083 PMID24473083 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24473083/
RECORD: Rec_0080750 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-MERS-CoV Fusion inhibition
inhibition of MERS-CoV infection in HFL cells
13.9 μM
IC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperStructure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor. | Lu L, Liu Q, Zhu Y, Chan KH, Qin L, Li Y, Wang Q, Chan JF, Du L, Yu F, Ma C, Ye S, Yuen KY, Zhang R, Jiang S. | Nat Commun. 2014;5:3067. | DOI:10.1038/ncomms4067 | PMID:24473083 PMID24473083 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24473083/
RECORD: Rec_0113340 VERIFIED: YES
Provenance & Taxonomy
Middle East respiratory syndrome-related coronavirus isolate United Kingdom,H123990006,2012 [Virus]
HR2-derived fusion inhibitor
1263720
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Middle East respiratory syndrome-related coronavirus isolate United Kingdom/H123990006/2012
0.85 μM
IC50
PaperStructure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor PMID24473083 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24473083/
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