Peptide Database

Peptide NameSLAY-screened peptide P409

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC110H178N32O23

DescriptionStandard

        IAVGPVGRIRFPRLTFRFTL
    

Molecular Weight2316.79 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)3.76

Net Charge (pH 7.4) 3.56

Charge Density (pH 7.0) 0.1880

GRAVY Index0.59

Hydrophobic Moment 0.65

Boman Index0.11

Instability Index22.67

Aliphatic Index 112.00

Aromaticity 0.1500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 886.70

LogP -5.06

H-bond Donors 33.0

H-bond Acceptors 27.0

Rotatable Bonds 71.0

Heavy Atoms 165.0

Ring Count 5.0

Amide Bonds 19.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0166936 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/