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MYP_039507
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Basic Information
MERS-S (1252-1286)
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
35 amino acids
C182H302N42O59S
Standard
Sequence
LTQINTTLLDLTYEMLSLQQVVKALNESYIDLKEL
Physicochemical Analysis
4054.66 Da
4.18
-3.23
-3.45
-0.0924
0.16
0.61
0.13
17.90
142.00
0.0571
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1668.55
-12.77
56.0
57.0
140.0
284.0
2.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0074247 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
MERS-COV(Middle East respiratory syndrome coronavirus):inhibition of MERS-CoV PsV infection in 293T/Huh7 cells
EC50
PMID24067982 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24067982/
RECORD: Rec_0164050 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
MERS-CoV PsV
PMID24067982 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24067982/
RECORD: Rec_0316179 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-MERS-CoV Fusion inhibition
MERS-COV (Middle East respiratory syndrome coronavirus) | 293T/Huh7 cells
3.013 μM
EC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperStructure of the fusion core and inhibition of fusion by a heptad repeat peptide derived from the S protein of Middle East respiratory syndrome coronavirus. | Gao J, Lu G, Qi J, Li Y, Wu Y, Deng Y, Geng H, Li H, Wang Q, Xiao H, Tan W, Yan J, Gao GF. | J Virol. 2013 Dec;87(24):13134-40. | DOI:10.1128/JVI.02433-13 | PMID:24067982 PMID24067982 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24067982/
RECORD: Rec_0333058 VERIFIED: YES
Provenance & Taxonomy
Middle East respiratory syndrome-related coronavirus isolate United Kingdom,H123990006,2012 [Virus]
HR2-derived fusion inhibitor
1263720
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Middle East respiratory syndrome-related coronavirus isolate United Kingdom/H123990006/2012
3.013 μM
IC50
PaperStructure of the fusion core and inhibition of fusion by a heptad repeat peptide derived from the S protein of Middle East respiratory syndrome coronavirus PMID24067982 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24067982/