Peptide Database

Peptide NameSLAY-screened peptide P1290

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC97H142N32O36S2

DescriptionStandard

        CTRCHNAGNYPHTYNSSIQDD
    

Molecular Weight2396.49 Da

Isoelectric Point (pI)6.00

Net Charge (pH 7.0)-1.08

Net Charge (pH 7.4) -1.42

Charge Density (pH 7.0) -0.0515

GRAVY Index-1.34

Hydrophobic Moment 0.31

Boman Index-0.24

Instability Index68.43

Aliphatic Index 23.33

Aromaticity 0.0952

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1124.13

LogP -17.16

H-bond Donors 40.0

H-bond Acceptors 39.0

Rotatable Bonds 73.0

Heavy Atoms 167.0

Ring Count 5.0

Amide Bonds 24.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0213995 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/