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MYP_039280
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Basic Information
MU89 (Octa 1 dp)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Enzyme modulation ▸ Enzyme inhibition ▸ Binding inhibition
Standard
16 amino acids
C132H176N46O19
Standard
Sequence
RRWYRWWRRRWYRWWR
Physicochemical Analysis
2711.11 Da
12.00
7.76
7.55
0.4849
-2.75
0.84
-0.93
238.84
0.00
0.5000
35980.00
35980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1130.22
-1.98
49.0
27.0
79.0
197.0
14.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0107931 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HSV-1:inhibition of virus infection in NP-2/CD4/CCR5 cells
8.3 μM
IC50
PaperPubMed PMID: 17681018 PMID17681018 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17681018/
RECORD: Rec_0166344 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HSV Binding inhibition
HSV-1 | NP-2/CD4/CCR5 cells
8.3 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperApolipoprotein E-derived antimicrobial peptide analogues with altered membrane affinity and increased potency and breadth of activity. | Kelly BA, Neil SJ, McKnight A, Santos JM, Sinnis P, Jack ER, Middleton DA, Dobson CB. | FEBS J. 2007 Sep;274(17):4511-25. | DOI:10.1111/j.1742-4658.2007.05981.x | PMID:17681018 PMID17681018 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17681018/
RECORD: Rec_0250916 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 17681018 PMID17681018 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17681018/
RECORD: Rec_0277986 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antiviral
Anti-HSV1 activity was assessed by plaque reduction assay
PMID17681018 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17681018/
RECORD: Rec_0308990 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antiviral
Staphylococcus aureus
PMID17681018 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17681018/
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