Peptide Database

Peptide NameBeta-defensin 119

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length82 amino acids

Chemical FormulaC432H673N119O117S10

DescriptionStandard

        MKFFLFFVILLAMEPVISGKHHILRCMGNTGICRPSCRKTEQPYLYCLNYQSCCLQSYMRISISGREEKDDWSQQNRWPKIS
    

Molecular Weight9726.34 Da

Isoelectric Point (pI)9.04

Net Charge (pH 7.0)4.62

Net Charge (pH 7.4) 4.19

Charge Density (pH 7.0) 0.0563

GRAVY Index-0.28

Hydrophobic Moment 0.55

Boman Index-0.03

Instability Index83.93

Aliphatic Index 74.88

Aromaticity 0.1220

Extinction Coeff. Reduced 16960.00

Extinction Coeff. Oxidized 17335.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3827.44

LogP -32.78

H-bond Donors 140.0

H-bond Acceptors 134.0

Rotatable Bonds 322.0

Heavy Atoms 678.0

Ring Count 18.0

Amide Bonds 89.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0055630 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus familiaris [Animal]

FamilyDefensin

Tax ID9615

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q30KT5/entry; https://bblserver.org.in/ampdb/