Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length398 amino acids

Chemical FormulaC1983H3167N519O551S16

DescriptionStandard

        MARGPDDTWRWATLVMLAALGTAVTATTNPGVVARITQKGLDYACQQGVATLQKELEKITIPTLSGSFKVKHLGKGKYSFYSLVIHGFKLPNSQIRPLPNQGLDLSIKDASIKMSGKWKARKSFIKVSGKFDLSVEGISILAALKLGYDPTSGHATVACSSCRSHINSVRVRISRSSLGWLIQLFHKKIESSLRNSMNRKICEVVTSAVSSKLQPYFQTLPVTTKIDNVAGIDYSLVAPPKATADSLDGLLKGEFFRLAHRRPPPFAPPALTLPTDHNRMVYLGISEYLFNTAGLVYQEAGVLNLTLSNDMLPKKSKFFLTTKFFGTLLPQVAKMFPDMKMQLLIWAPSPPNVAVCPTGLDLTFSLDTQAVAVLPDSSLAPLFLLEMGLRLEPLSYCF
    

Molecular Weight43607.55 Da

Isoelectric Point (pI)9.65

Net Charge (pH 7.0)18.06

Net Charge (pH 7.4) 17.31

Charge Density (pH 7.0) 0.0454

GRAVY Index0.08

Hydrophobic Moment 0.66

Boman Index0.11

Instability Index39.54

Aliphatic Index 97.29

Aromaticity 0.0854

Extinction Coeff. Reduced 42400.00

Extinction Coeff. Oxidized 42775.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0056393 VERIFIED: NO

Provenance & Taxonomy

OrganismBalaenoptera acutorostrata scammoni [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence